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ANZMOSS - ANZGOSA 2020 Virtual Conference
ANZMOSS – ANZGOSA 2020 Virtual Conference
ANZMOSS - ANZGOSA 2020 Virtual Conference
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Pathophysiological mechanisms of gastro-oesophageal reflux following sleeve gastrectomy

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Presentation Description

BACKGROUND
Gastro-esophageal reflux (GERD) post-SG is a critical issue due to symptom severity, impact on quality of life, requirement for re-operation, and potential for Barrett’s esophagus. The pathophysiology is incompletely delineated. We aimed to to evaluate the mechanisms associated with reflux events following sleeve gastrectomy (SG).
 
METHODS
Post-SG patients, stratified into asymptomatic and symptomatic, underwent protocolized nuclear scintigraphy (n=83), 24-hour esophageal pH monitoring, and stationary manometry (n=143) to characterize reflux patterns. Ten patients underwent fasting and post-prandial concurrent manometry and pH for detailed analysis of reflux events.
 
RESULTS
Baseline demographics between cohorts were similar: Age 47.2±11.6 vs. 44.1±11.3 years (p=0.121); females 73.2% vs. 90.8% (p=0.005); excess weight loss (EWL) 53.8±28.1% vs. 57.4±25.5% (p=0.422), follow-up duration 12.3 vs. 7.4 months (p=0.503). Nuclear scintigraphy delineated bolus-induced deglutitive reflux events (29.6% vs. 62.5%, p=0.005) and post-prandial reflux events (4(IQR2) vs. 4(IQR 3) events, p=0.356). Total acid exposure was significantly elevated in the symptomatic population (7.7% vs. 3.6%, p<0.001), especially fasting acid exposure (6.0% vs.1.3%, p<0.001). pH/manometry analysis demonstrated acute elevations of the gastro-esophageal pressure gradient (>10mmHg) underpinned most reflux events. Swallow-induced intragastric hyper-pressurization was associated with individual reflux events in most patients (90% in fasting state and 40% post-prandial).
 
CONCLUSIONS
We found reflux to be strongly associated with SG and identified three unique categories. Bolus-induced deglutitive and post-prandial reflux occurred in most patients. Elevated fasting esophageal acid exposure mediated symptoms.  Frequent, significant elevation in the gastro-esophageal pressure gradient was the mechanism of reflux and appeared to relate to the non-compliant proximal stomach.

Authors

Paul Burton - Monash University Wendy Brown - Monash University Geoffrey Hebbard - Melbourne University Kenneth Yap - Alfred Health Paul Beech - Alfred Health Julie Playfair - Monash University Cheryl Laurie - Monash University Geraldine Ooi - Monash University Jarrel Seah - Alfred Health Helen Yue - Alfred Health Anagi Wickremasinghe - Monash University Gillian Lim - Monash University Yazmin Johari - Monash University

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